Coenzyme Q10 Benefits

By Stephen T. Sinatra, M.D., F.A.C.C., F.A.C.N., C.N.S., C.B.T.

As a nutrient essential to energy production, coenzyme Q10, also known as CoQ10, is a VIP (very important particle) within your body. It is one of the best nutrients you can feed your heart to support overall heart health, and I cannot imagine practicing cardiology without it.

What’s so special about Coenzyme Q10? This fat-soluble, vitamin-like compound is found within all your body’s cells and helps your body (and especially your heart) make the energy it needs to function and stay healthy.

Coenzyme Q10 and Heart Health Benefits

What Are Mitochondria?

To really understand why CoQ10 is so important, we need to take a look under the microscope… at all our  individual cells.

Inside our cells are tiny organelles called mitochondria – microscopic power plants that produce all the energy molecules that our bodies run on. Those energy molecules are called ATP, or adenosine triphosphate (you can learn more about ATP in this article). Among other crucial functions, your body uses ATP to keep your heart beating.  Since our hearts require an enormous amount of energy to sustain us, they contain more mitochondria than all other organs in the body.

How does CoQ10 help you make energy? Specifically, it helps your mitochondria regenerate ATP by assisting enzymes with electron transfer. In this role, CoQ10 acts as a coenzyme and is functioning in its whole form: ubiquinone.

Coenzyme 10’s power doesn’t stop here, though. It actually plays a another highly important role in your body as an antioxidant. After it helps your mitochondria with ATP regeneration, the efficient CoQ10  – in its reduced form, ubiquinol – serves as an antioxidant, protecting heart cell membranes and mitochondria from oxidative damage. Ubiquinol even travels through your bloodstream to quench free radicals and prevent oxidation of LDL in blood vessels.

Heart muscle requires an incredible amount of CoQ10 to circulate oxygenated and nutrient-rich blood through your body. In fact, tissue levels of CoQ10 are usually ten times higher in the healthy heart than any other organ of the body, even the brain! It truly is your heart’s best friend.

CoQ10 Foods and Other Sources of Coenzyme Q10

Your body makes its own supply of coenzyme Q10 from amino acids, vitamins and minerals. However, around the age of 40, the body’s production of CoQ10 begins to decline, which impacts your ability to generate ATP.

CoQ10 deficiency can be the result of age, malnutrition, or drug interference, and is associated with many heart conditions. CoenzymeQ10 levels can also drop if you’re not getting enough of the various nutrients required to synthesize it, or if you’re taking statin drugs or beta blockers. The good news is, you can build up your supply of CoQ10 by consuming coQ10-containing foods and supplements.

Good food sources of coenzyme Q10 include fish like sardines and wild Alaskan Salmon, meats, broccoli, spinach, and nuts. And although many people wouldn’t dream of eating organ meats like the heart or liver, they are some of the most concentrated food sources of CoQ10.

Coenzyme Q10 supplements can be a more reliable (not to mention palatable)  way to get more of this crucial nutrient as we age. Commercial CoQ10 supplements may vary in potency. You should look for a supplement that is bioavailable enough to significantly raise CoQ10 levels in your blood. Bioavailability describes how quickly, and in what concentration, your blood absorbs substances. Water- and fat-soluble forms of CoQ10 tend to be more bioavailable than dry powder blends. Blood levels of CoQ10 provide the most accurate assessment of how much CoQ10 is being absorbed and delivered to your tissues. Researchers agree that a 2.5 µg/ml blood level of CoQ10 is optimal, while 3.5 µg/ml is the preferred amount for people with severely diseased hearts.

How Much Coenzyme Q10 Should You Take?

With my patients, I always prescribed CoQ10 as part of their treatment plans, and would also recommend it to facilitate heart health and healthy aging in the following amounts:

  • 50 to 100 mg daily for otherwise healthy people between the ages of 40 and 60;
  • 100 to 200 mg daily for people who take statin drugs or are over the age of  60;
  • 180 – 360 mg daily for those with hypertension (high blood pressure);
  • 300 – 600 mg daily for those with CHF (Start with 180 mg and work up to 300+ mg over three weeks);and
  • 600 – 1,200+ mg daily for people with Parkinson’s disease and other debilitating illness such as cancer.

In addition to supporting heart health, CoQ10 supplementation can help cancer patients who receive Adriamycin, a form of chemotherapy, protect their hearts against the agent’s toxic effects. Supplementation with CoQ10 can also offset nutritional deficiencies caused by pharmaceutical drugs like beta blockers, statins, and antidepressants. Note: careful monitoring for drug interactions is suggested when blood thinners like Coumadin are in the picture.

It’s important to realize that there are no “cut-and-dry” guidelines about coenzyme Q10 dosages – what’s right for others, may not be right for you. Bottom line is that the “right” amount of coenzyme Q10 to take is the amount that helps makes YOU – the individual – feel better (remember to keep your doctor informed of the dosages of supplements you are taking).

Here are some addutional CoQ10 Facts: CoQ10 Benefits, Dosage and More.

© 2015, 2018 HeartMD Institute. All rights reserved.

Leave a Reply


  1. Julia Petty

    on June 10, 2014 at 4:50 pm

    Your article says “CoQ10 also offers cardiovascular protection by decreasing your risk of blood clots.” So taking CO-Q10 with blood thinner medicine at the same time should cause bleeding phenomenon, right? In fact, after orally administating these two, my mother suddenly breathed difficultly in sitting position with oxygen supply. It obviously caused quick and large blood clots. Good thing is we prayed and 5 minutes later she suddenly felt healed. According to your article, it should cause bleeding instead of clotting. Another article says co q 10 increases blood clotting because these two work together to cause large blood clots. Shouldn’t blood clotting + blood thinner = 0? Both explanations make me confused. how to take coq10 with blood thinner?

  2. Yvonne

    on June 20, 2015 at 9:43 am

    I also read an article where it says that CQ10 can cause blood clots. I am no daily aspirin, betablocker and statin after heart attack 3 years ago requiring a what does one believe?
    I was taking clopidogrel plus daily aspirin for just over 12 months after my heart attack, then went off clopidogrel and stayed on the aspirin daily.
    Can this contradictory information regarding Coenzyjme Q10 please be clarified?
    Does it cause blood clots… or not??//

  3. HMDI Editor

    on June 24, 2015 at 2:14 pm

    We, the HMDI editors as well as Dr. Sinatra, have never heard of any such research findings; coenzyme Q10, as stated above, actually helps reduce risk of blood clots. Do you recall the source of the conflicting information?

  4. Daisy Campbell

    on October 6, 2015 at 3:22 am

    I Daisy Campbell thank you Dr.sanatra for all your tips on medication how it can help our bodies . I see you talks about coq-10 how good and powerful it is for the body . Thank you I have a question what can be taken for thyroid besides levothyroxine I have the one that make you gain weight . Is there any thing you can take naturally other then the medication please give me a answer thank you Daisy Campbell

  5. David K.

    on November 3, 2017 at 11:24 am

    Dr.Sinatra and staff: I am currently on atenolol 50 mg divided dose AM/PM.My question is can I take a small dose of COQ10 For support while taking Atenolol? I have heard many viewpoints on this? Thank you. David Keyishian.

  6. HeartMD Editor

    on November 28, 2017 at 12:08 pm

    Hi David,

    Dr. Sinatra has had many patients take CoQ10 while on beta blockers. Please discuss supplementing with it with your doctor.

  7. Terry

    on December 19, 2017 at 10:23 am

    Thanks for sharing your insightful knowledge with us. Much appreciated. I look forward to reading your suggestions for better heart health.

  8. Phyllis Robinson

    on February 12, 2018 at 7:29 am

    I have used the awesome foursome for years and I love these supplements!

  9. Joh Imo

    on April 13, 2018 at 7:09 am

    Need to read more about the heart

  10. Francie Epperson

    on March 19, 2019 at 4:58 pm

    Is there a particular brand he recommends for the CoQ10? I can’t find it in the article. Thanks.

  11. HeartMD Editor

    on April 2, 2019 at 12:13 pm

    Hi Francine,
    Dr. Sinatra’s formulations are at

  12. Donna

    on September 13, 2019 at 10:40 am

    I’m on Entresto, Carvedelol, aspirin and Eliquis after a mini stroke in April. Cardiomyopathy from chemo therapy and EF at 30%. I’m not sure about taking the “awesome foursome” with my meds. My cardiologist is not a fan of supplements but I’m concerned about taking these with the meds I’m on. Can you offer any advice?

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