Best Supplements to Lower Blood Pressure

By Stephen T. Sinatra, M.D., F.A.C.C., F.A.C.N., C.N.S., C.B.T.

My integrative strategy against hypertension, which encompasses the adoption of a non-inflammatory diet and moderate exercise regime, healthy stress management and possible pharmaceutical treatment (among other behavioral modifications), necessarily includes supplementation for nutritive support. Targeted nutritional supplements not only provide our bodies substances necessary for protection and repair of cardiovasculature, they facilitate energy production within the heart and the rest of the body.

Maintaining and improving structural integrity of the heart and blood vessels through nutritive support is crucial for blood pressure management.

Melatonin and Blood Pressure

Top Supplements for Blood Pressure Lowering:

1.     Coenzyme Q10 (CoQ10) – 100 mg twice per day

2.     Nattokinase – 50 mg twice per day

3.     Omega 3-Fish Oil – 2 to 3 gms per day

4.     Magnesium – 400 to 800 mg per day

5.     Garlic – 1,000 mg per day

6.     Hawthorne – 1,000 to 1,500 mg per day

7.     Vitamin D – 1,000 to 2,000 units per day

8.     Quercetin – 500 mg twice per day

9.     Folate – 800 mg per day

10.   Vitamin C – 1,000 mg per day

11.   Argenine – 2 g per day

12.   Crushed Flaxseed – 1 to 2 Tbsp per day

13.   Grapeseed extract 150 mg per day

While multiple nutraceuticals can support blood pressure lowering, taking every one on list above is not for everyone. Based on my experience with them in clinical practice, my top supplement choices are listed as numbers one through six above. For patients with congestive heart failure, I suggest increasing CoQ10 intake to 100 mg 3 to 4 times per day, and adding 2,000 to 3,000 mg L-carnitine and 15 g ribose in divided doses per day to at least the top six.

So Many Dietary Supplements – How Do You Choose?

Note: Patients taking medication for high blood pressure should always discuss any potential changes to their blood pressure-lowering strategies, including supplementation and/or other lifestyle modifications, with their physicians.

© 2009, 2016 HeartMD Institute. All rights reserved.

Leave a Reply


  1. deb

    on April 11, 2014 at 9:43 am

    I am coming off warfarin due to carotid dissection which has healed. I am type a personality/perfectionist. Would it be appropriate to take 1-6 on the list on daily basis to maintain healthy levels and improved pressure?
    Thank you.

  2. Tony

    on September 19, 2014 at 2:36 pm

    I was told that i have hypertension 2 what you think i should do?

  3. Tony

    on September 19, 2014 at 2:37 pm

    what should i do for hypertension 2

  4. regina

    on June 19, 2015 at 2:43 pm

    am 75 taking amiodarone for atrial arrythmya ,how risky is it to get a cateter ablation?

  5. Lida Krieger

    on October 6, 2015 at 2:38 pm

    which of those supplements should be avoided if there is a history of breast cancer and if you are on low dose aspirin therapy?

  6. bruce m.

    on August 31, 2017 at 2:15 pm

    I take metoprolol 50mg and amlodpine besylate 5mg daily along with a 81mg baby aspirin.
    I’m only 24lbs over my recommended weight and I’m exercising and eating healthy every day.
    I’d like to cut these two main prescriptions and work on natural suppliments and foods to get my BP to a everyday 125/79.
    Is this possible and what direction would you point me in?
    Thank you kindly for your advice and thank you for what you are doing for all of us out here.

  7. HeartMD Editor

    on September 12, 2017 at 11:08 am

    Hi Bruce,

    Doctor Sinatra cannot give direct medical advice. You might want to try consulting with one of the cardiologists on Dr. Sinatra’s Top Docs List – see it here. Additionally, you might find this video helpful. You can also refer to Dr. Sinatra’s Book: Lower Your Blood Pressure in 8 Weeks.

  8. Althea Scott

    on April 1, 2018 at 10:43 am

    I have blood pressure problem, my blood pressure is always up and down, I basicly eat baked broiled food veggies some fruit. I exercise every other day. I have a total gym, pro-form walker, trampaline and 5lbs weight. I do not know what else to do

  9. HeartMD Editor

    on April 12, 2018 at 9:44 am

    Hi Althea,

    You may want to consider incorporating some of the targeted nutritional supplements discussed on this page.

    Additionally, you can refer to Dr. Sinatra’s book: Lower Your Blood Pressure in Eight Weeks.

  10. cindy

    on June 17, 2018 at 12:27 pm

    I am trying Natures Truth Super Strength Water Pill with Potassium. Do you think this will help high blood pressure? Was recommended by a non doctor is why asking. Is vegan and all natural.

  11. Ann

    on September 7, 2018 at 6:32 pm

    Can you comment on which supplements to avoid when on medication such as Ramipril? I read that Hawthorne should be avoided.. Are there others? How long should I wait after stopping Hawthorne before starting medication?

  12. Patti

    on June 19, 2019 at 6:01 pm

    Why we cannot receive the nattokinase anymore?

  13. Robert Merkel

    on December 15, 2020 at 2:19 pm

    Out of the 10 mentioned supplements above, if I get the first 5, shall I take one of each per day?

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