20 Ways to Preserve Brain Health As You Age

By Stephen T. Sinatra, M.D., F.A.C.C., F.A.C.N., C.N.S., C.B.T.

“Dr. Sinatra: How can I keep my brain and memory sharp as I get older?” That’s a question I’ve been asked countless times and you’ll be surprised at the number of options you have. Unfortunately, there is no magic pill for brain health, but I’ve got 20 effective strategies you can do to help slow down the aging process and protect your marbles.

I’ll share those brain health savers in a minute. First, here are some facts you should know…  

As we get older our brain changes just like the rest of our body. Alas, the changes mean less efficiency.  Starting in our 60s or 70s, our brain mass may downsize a bit. Among the parts that shrink more than others is the frontal lobe containing the prefrontal cortex − the CEO of the brain, so to speak − and the hippocampus where new memories are formed.

The outer surface of the brain thins out somewhat due to a loss in synaptic connections, meaning the communication paths between brain cells. The white matter also ages, resulting in a slowdown of memory, attention, action, and problem solving. White matter is fatty tissue that acts as electrical insulation and channel through which messages pass between different areas of the nervous system’s grey matter. Aging brains also produce less neurotransmitters which carry messages between brain cells.

That’s the bad news. Now here’s what you can do to protect your brain health:

Can Adults Grow New Brain Cells?

20 Ways to Keep Your Brain Healthy

1. Keep your cool. Stress − in the form of emotional, mental, or physical tension − can physically reshape and shrink the brain and cause long-lasting harm. Stress can aggravate or lead to Parkinson’s, Alzheimer’s and other neurodegenerative diseases. Defuse your stress with meditation, prayer, yoga, tai chi, or the pursuit of some enjoyable hobby. It is worth remembering the words of Hans Selye, M.D., the world-famous doctor who first coined the term stress decades ago: “Every stress leaves an indelible scar, and the organism pays for its survival after a stressful situation by becoming a little older.”

2. Find ways to be happy, positive and optimistic. You’re more likely to live longer and your brain health will benefit!

3. Keep your blood pressure under control. Stress reduction will help accomplish that. High blood pressure can choke off oxygen to the brain. Approximately 20 percent of the oxygen you breathe in goes to your brain. If you have high blood pressure, I suggest you reduce it for both heart and brain health. Additionally, recent research has shown that even a glass of beetroot juice and some green leafy vegetables can make a difference.  

4. Exercise regularly. You don’t have to run marathons or become a gym rat: walk, dance, do tai chi. Just get moving doing whatever you enjoy. Physical activity increases circulation to the brain. It also produces a hormone called brain-derived neurotrophic factor that promotes preservation of existing neurons and the creation of new ones. The hormone is active in the hippocampus and prefrontal cortex, areas vital to learning, memory, and higher thinking. Exercise also promotes the neurotransmitters serotonin (a mood elevator) and dopamine (important for focus).

5. Flex your brain just as you would any muscle: learn new skills, do puzzles, play chess or card games. Heed the words of tennis icon Jimmy Connor who said, “use it or lose it.”

6. Cut down on processed carbs. The standard American diet, high in processed carbohydrates and added sugars, is a brain health buster. Processed carbohydrates mean sodas, typical packaged breakfast cereals, and white flour pasta, bread, cakes and cookies. These manufactured “foods” convert quickly into blood sugar and create excess insulin release, eventually triggering inflammation, metabolic syndrome, and diabetes. When sugar combines with proteins in the blood they form so-called advanced glycation end products (AGEs), substances that can damage the highly sensitive inner lining of the arteries, whether they lead to your heart or your brain. A 2013 study from the University of Washington found that higher levels of blood sugar represent a risk factor for dementia. Additionally, according to a 2012 Mayo Clinic study, a dietary pattern with a relatively high intake of carbohydrates raises the risk of cognitive impairment or dementia in elderly persons, while a high intake of fat and protein lowers the risk.

7. Follow my PAMM diet, a combination of the healthy Mediterranean and Asian diets that is full of optimal food for the brain. It is rich in fruits and vegetables, fish, and healthy fats. A Mediterranean diet, reinforced with extra-virgin olive oil or nuts, has been found to improve brain function in older adults.

8. Fruit and vegetables are among the most brain healthy foods. Antioxidant-rich berries, especially, contribute to brain power. Blueberries, in particular, are high in antioxidants called anthocyanins that can actually enhance your brain cells’ ability to communicate with each other. The most beneficial vegetables are leafy greens like spinach, and the cruciferous varieties such as broccoli, cauliflower, and kale. Try to eat produce that is organic to minimize your intake of pesticides.

9. Among other brain healthy foods, the combination of antioxidant-rich spinach and free-range, organic eggs helps protect your memory. The healthy fat in egg yolk allows beneficial nutrients in the spinach to be fully absorbed by the body. Spinach omelet? Yes, please!

10. The brain needs fat. Eat healthy, anti-inflammatory foods for the brain like nuts, seeds, fish such as wild-caught salmon and sardines, and avocados on a daily basis. They protect and fortify brain health. Generously drizzle your vegetables and salads with extra virgin olive oil (my all-time favorite healthy fat!). Don’t be afraid of butter. Cook with coconut oil.

Health Benefits of Olive Oil

11. Heart healthy HDL cholesterol not only protects against heart disease and stroke, but can provide protection against dementia as well. The best way to raise your HDL level is to make vegetables and fruits the largest part of your diet. A daily handful of blanched almonds is an easy way to raise your HDL. Optimism in life is another way to raise HDL.

12. Nutritional supplements benefit your brain in many ways. Here’s a list of key brain health supplements:  

a. A high-quality multiple vitamin, mineral, and antioxidant formula. A good multi is the backbone of any effective nutritional program. The formula should contain more than the RDA of the major factors in the B complex family, vital for maintaining the integrity of the nervous system. You may also want to include extra B-12 (100 to 200 mcg), which becomes depleted in the elderly, along with 100-250 mg niacin (B-3).

b. Omega-3 Marine oil, 2-3 grams. The brain is high in fatty tissue, including docosahexaenoic acid (DHA), an important constituent in squid or fish oil that is an anti-inflammatory that has been found to protect neuronal function. Researchers have found that supplemental DHA improves memory and learning in individuals with age-related cognitive decline.

c. Coenzyme Q10 (CoQ10), an essential antioxidant and raw material to feed and protect cellular energy production. Research shows it can help protect against dementia. Take 100–200 milligrams per day.

d. Acetyl-L-carnitine (ALC), a brain-boosting form of the amino acid carnitine. ALC is an antioxidant, membrane stabilizer and enhancer of cellular energy. It can also slow down mental decline. Take 125–250 milligrams per day.

e. Alpha lipoic acid (ALA), another potent antioxidant. Take 100–200 milligrams daily.

f. Phosphatidylserine is a nutrient involved in cellular membranes that helps increase memory and cognitive function. Take 100-200 milligrams daily. Phosphatidylcholine, a related nutrient, promotes neurotransmitter and nerve impulse activity. Take 75–150 mg per day.

13. A glass of wine four to six times a week has been found to benefit brain function and slow down mental decline. Drinking more is harmful because alcohol damages the liver and brain.

14. Add garlic to your diet. Garlic packs natural chemical compounds that many laboratory studies have shown to have neuroprotective and anti-inflammatory benefits. 

15. The curry spice turmeric and its pigment extract curcumin rank among the most potent food-derived anti-inflammatory agents, and may help counteract plaque in the memory circuits of the brains of Alzheimer’s patients. One Japanese study provides a promising glimpse at how turmeric may be helpful for patients. 

16. Be wary of cholesterol lowering statin drugs. I strongly believe that overzealous prescribing of statins represents a genuine threat to brain health and here’s why: Life can’t go on without cholesterol, a basic raw material made by your liver, brain, and almost every cell in your body. The brain is particularly rich in cholesterol and accounts for about a quarter of all the cholesterol we have. The fatty myelin sheath that coats every nerve cell and fiber is about one-fifth cholesterol. Neuronal communication depends on cholesterol. It is not surprising that a connection has been found between naturally occurring cholesterol and mental function. Lower levels are linked to poorer cognitive performance. Lowering cholesterol to abnormally and unnaturally low levels contributes to Alzheimer’s, particularly in people over 75. I don’t recommend it for prevention, only for middle-aged men with a history of heart disease and very high risk women.

17. Grounding (also known as Earthing) is a powerful, simple, and natural anti-aging strategy for whole body and brain health. All you need to do is walk/sit barefoot outdoors for a half-hour or so daily or use conductive Earthing bed sheets, mats, or bands indoors, activities that give you contact to the Earth’s gentle, negative charge. Research is showing that such contact can reduce inflammation and stress, improve blood flow, and promote better sleep.    

18. We live in an increasingly toxic environment. Along with all the pesticides, insecticides, and chemical pollutants, we also are immersed in proliferating wireless technologies that create unseen chaotic electrical frequencies – especially now that 5G is being rolled out. The combination of all these factors may be harmful to young and old alike.  Eat organic food, purify your air and water, and spend time in nature, while limiting your exposure to WiFi and cell phone radiation.

Forest Bathing: Enjoying Nature’s Health Benefits

19. Healing music. Play the music of your youth, which can foster memories and social interactions as well as alleviate stress. Also tune into whatever music currently touches your soul, especially if it inspires you to dance!

20. If you have a family history of Alzheimer’s or dementia, get tested for a genetic predisposition. Check with your doctor. Specifically, the test will look for the APO E4 allele. APO refers to a blood protein involved in fat metabolism. Alleles are combinations of genes. The presence of two alleles identified as E4 in these proteins suggests you need to be extra mindful about protecting yourself, not just for the risk of dementia but also heart disease.


© Stephen Sinatra, MD. All rights reserved.

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